The Global Pesticide Grids (PEST-CHEMGRIDS), Version 1.01 data set contains 20 of the most-used pesticide active ingredients on 6 dominant crops and 4 aggregated crop classes at 5 arc-minute resolution (about 10 km at the equator), estimated in year 2015, and then projected to 2020 and 2025. To estimate the global application rates of specific active ingredients, spatial statistical methods were used to re-analyze the U.S. Geological Survey Pesticide National Synthesis Project (USGS/PNSP) and the Food and Agriculture Organization Corporate Statistical Database (FAOSTAT) pesticide databases, along with other public inventories including globally gridded data of soil physical properties, hydro-climatic variables, agricultural quantities, and socioeconomic indices. The application rate (APR) of each active ingredient on each crop is in kilogram per hectare per year (kg/ha-year), and the harvest area of each crop is in hectare (ha). The data set also includes 200 data quality index maps corresponding to each active ingredient on each crop, as well as maps of the 10 dominant crops and 4 aggregated crop classes. Version 1.01 includes data in GeoTIFF and netCDF formats.