This dataset includes total suspended solids (TSS) at the water surface across the Atchafalaya and Terrebonne Basins in Southern Louisiana, USA, within the Mississippi River Delta (MRD) floodplain. AVIRIS-NG, the Next Generation Airborne Visible to Infrared Imaging Spectrometer, acquired data over the study area in 2015 and 2016. The remote imageries were combined with coincident field measurements to develop and validate spatially explicit estimates at 3.7-5.4 m resolution of the concentration (mg/L) of TSS.