This dataset provides gridded surface-atmosphere CO2 fluxes over North America from April 8 to November 18 during 2018 and 2019. Net ecosystem exchange (NEE) was estimated by the CMS-Flux-NA CO2 inversion system by assimilating in situ CO2 measurements and/or Orbiting Carbon Observatory (OCO-2) column-averaged CO2 retrievals. These data, along with imposed diurnal NEE variations, fossil fuel emissions, biomass burning, and biofuel emissions, are provided at 3-hour temporal resolution. The modeled co-samples of CO2 observed for aircraft flights are included for model evaluation. The data are provided in NetCDF version 4 format.